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匹配条件： “Jagadeesh K Venkatesan” ，找到相关结果约178690条。
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Comparison of AMSR-2 wind speed and sea surface temperature with moored buoy observations over the Northern Indian Ocean
B Nanda Kishore Reddy,Jagadeesh Kadiyam,K Jossia Joseph,Krishna K Osuri,R Venkatesan,Simi Mathew
- , 2018,

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rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
Henning Madry,Jagadeesh K. Venkatesan,Gertrud Schmitt,Sarah Schetting,Myriam Ekici,Dieter Kohn,Magali Cucchiarini
Sarcoma , 2012, DOI: 10.1155/2012/347417

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SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn, Magali Cucchiarini
Stem Cell Research & Therapy , 2012, DOI: 10.1186/scrt113

Abstract: The rAAV-FLAG-hSOX9 vector was provided to both undifferentiated and lineage-induced MSCs freshly isolated from patients to determine the effects of the candidate construct on the viability, biosynthetic activities, and ability of the cells to enter chondrogenic, osteogenic, and adipogenic differentiation programs compared with control treatments (rAAV-lacZ or absence of vector administration).Marked, prolonged expression of the transcription factor was noted in undifferentiated and chondrogenically differentiated cells transduced with rAAV-FLAG-hSOX9, leading to increased synthesis of major extracellular matrix components compared with control treatments, but without effect on proliferative activities. Chondrogenic differentiation (SOX9, type II collagen, proteoglycan expression) was successfully achieved in all types of cells but strongly enhanced when the SOX9 vector was provided. Remarkably, rAAV-FLAG-hSOX9 delivery reduced the levels of markers of hypertrophy, terminal and osteogenic/adipogenic differentiation in hMSCs (type I and type X collagen, alkaline phosphatise (ALP), matrix metalloproteinase 13 (MMP13), and osteopontin (OP) with diminished expression of the osteoblast-related transcription factor runt-related transcription factor 2 (RUNX2); lipoprotein lipase (LPL), peroxisome proliferator-activated receptor gamma 2 (PPARG2)), as well as their ability to undergo proper osteo-/adipogenic differentiation. These effects were accompanied with decreased levels of β-catenin (a mediator of the Wnt signaling pathway for osteoblast lineage differentiation) and enhanced parathyroid hormone-related protein (PTHrP) expression (an inhibitor of hypertrophic maturation, calcification, and bone formation) via SOX9 treatment.This study shows the potential benefits of rAAV-mediated SOX9 gene transfer to propagate hMSCs with an advantageous chondrocyte differentiation potential for future, indirect therapeutic approaches that aim at restoring articular cartilage defects i

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Abstract: Treatment of chondrosarcoma remains a major challenge in orthopaedic oncology. Gene transfer strategies based on recombinant adenoassociated viral (rAAV) vectors may provide powerful tools to develop new, efficient therapeutic options against these tumors. In the present study, we tested the hypothesis that rAAV is adapted for a stable and safe delivery of foreign sequences in human chondrosarcoma tissue by transducing primary human chondrosarcoma cells in vitro and in situ with different reporter genes (E. coli lacZ, firefly luc, Discosoma sp. RFP). The effects of rAAV administration upon cell survival and metabolic activities were also evaluated to monitor possibly detrimental effects of the gene transfer method. Remarkably, we provide evidence that efficient and prolonged expression of transgene sequences via rAAV can be safely achieved in all the systems investigated, demonstrating the potential of the approach of direct application of therapeutic gene vectors as a means to treat chondrosarcoma. 1. Introduction Chondrosarcomas are a complex group of primary solid cartilaginous tumors with variable clinical behavior and histopathology. They are classified as either central (skeletal) chondrosarcomas, including conventional, dedifferentiated, mesenchymal, or of clear cell subtype, or peripheral (extraskeletal) chondrosarcomas of myxoid type, from solitary osteochondromas, or associated with the hereditary multiple exostoses syndrome. These differences are reflected by the diversity of genetic abnormalities observed (chromosomal translocations, rearrangements, duplications, deletions) [1–4]. Among them, the conventional subtypes that are usually assessed according to clinicoradiologic and histopathological criteria from grade 1 to 3 [5–9] represent about 90% of skeletal chondrosarcomas. Surgical management of these tumors in individuals is currently the only curative treatment, as chondrosarcomas do not respond well to radio- and/or chemotherapy, indicating a potential need for novel therapeutic approaches. Large efforts have been made to understand the mechanisms underlying the pathogenesis of these tumors [1, 4, 10–13]. Indeed, evidence has been provided showing the alteration of tumor suppressors (p53, retinoblastoma) and the activation of oncogenes (c-myc), signaling axes (Bcl-2, Ihh/PTHrP, GH/IGF, FGF-2/FGFR1, survivin), or angiogenic factors (VEGF, FGF-2). Such findings may allow to identify new targets for therapy in addition to those already involved in cell proliferative and cartilage-related synthetic pathways (overexpression of type-II and

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Effects of TGF
Ann-Kathrin Asen,David Zurakowski,Gertrud Schmitt,Henning Madry,Jagadeesh K. Venkatesan,Lars Goebel,Magali Cucchiarini,Matthias W. Laschke,Michael D. Menger
- , 2018, DOI: 10.1177/0363546518773709

Abstract: Application of the chondrogenic transforming growth factor beta (TGF-β) is an attractive approach to enhance the intrinsic biological activities in damaged articular cartilage, especially when using direct gene transfer strategies based on the clinically relevant recombinant adeno-associated viral (rAAV) vectors. To evaluate the ability of an rAAV–TGF-β construct to modulate the early repair processes in sites of focal cartilage injury in minipigs in vivo relative to control (reporter lacZ gene) vector treatment. Controlled laboratory study. Direct administration of the candidate rAAV–human TGF-β (hTGF-β) vector was performed in osteochondral defects created in the knee joint of adult minipigs for macroscopic, histological, immunohistochemical, histomorphometric, and micro–computed tomography analyses after 4 weeks relative to control (rAAV-lacZ) gene transfer. Successful overexpression of TGF-β via rAAV at this time point and in the conditions applied here triggered the cellular and metabolic activities within the lesions relative to lacZ gene transfer but, at the same time, led to a noticeable production of type I and X collagen without further buildup on the subchondral bone. Gene therapy via direct, local rAAV–hTGF-β injection stimulates the early reparative activities in focal cartilage lesions in vivo. Local delivery of therapeutic (TGF-β) rAAV vectors in focal defects may provide new, off-the-shelf treatments for cartilage repair in patients in the near future

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Pharmacokinetics and drug interactions of newer anti -leprosy drugs
Venkatesan K
Indian Journal of Dermatology, Venereology and Leprology , 1997,

Abstract:

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The crystal structure of ammonium perchloratea？？NH4ClO4
K Venkatesan
- , 1957,

Abstract:

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Microwave-Induced, Iodine-Alumina Catalyzed Transformations of 1-(2′-hydroxyaryl)-3-(2-chloroquinolin-3-yl)-prop-2-en-1-one
P. Venkatesan,K. Moorthi
Journal of Chemistry , 2012, DOI: 10.1155/2012/354875

Abstract: The chalcone derivatives, 1-(2′-hydroxyaryl)-3-(2-chloroquinolin-3-yl)-prop-2-en-1-one was transformed to corresponding flavone derivatives by iodine impregnated neutral alumina under microwave irradiation. The synthesized flavone derivatives were structurally confirmed by elemental analysis, UV, IR and 1H-NMR spectral data, and the notable yield obtained was compared with previously reported method.

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Feedback From the First Supernovae in Protogalaxies:The Fate of the Generated Metals
K. Wada,A. Venkatesan
Physics , 2003, DOI: 10.1086/375335

Abstract: We investigate the chemo-dynamical effects of multiple supernova explosions in the central region of primordial galaxies using three-dimensional hydrodynamical simulations of the inhomogenous interstellar medium down to parsec-scales. We find that the final protogalactic structure and metal distribution depend strongly on the number of SNe. Specifically, 1) 1000 SNe after an instantaneous burst of star formation are sufficient to almost completely blow away the gas in these systems, whereas 2) 100 SN explosions trigger the collapse of the protogalactic cloud, leading to the formation of a cold, dense clumpy disk (n > 300 cm^-3) with metallicity, Z = 4 10^-4 Z_sun. These results imply that the metallicity of the ``second generation'' of stars could be Z ~ 10^-4 Z_sun, and that the environment to form metal-free stars in protogalaxies may be lost relatively quickly (< 10^7 yr) after the first burst of Z=0 star formation. The recently discovered ultra-metal-poor star (Christlieb et al. 2002) may represent surviving members of such second-generation star formation.

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Assessment of Safety Culture in Global Offshore Environments [PDF]
Jagadeesh Kilaparthi
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.511101

Abstract:

This project aims at presenting detailed assessment of health and safety culture in global offshore environments. Such assessment will be then utilized for developing and recommending a model capable of integrating safety behaviour and culture in global offshore environments. The global offshore environment is a quite wider term and therefore underlying study has specified and narrowed it down to the oil and gas industry. In other words, the discussion of health and safety culture is done in light of oil and gas industry and its environment. The proposed model “incident-free and low-risk contracting model” aims at fostering health and safety culture in oil and gas environments. It is worth mentioning that implementation of model requires effective support and collaboration between trade unions, industry associations, employers, and government agencies. The objectives of the proposed model will be identified in terms of Fostering sound leadership, Gaining management commitment, Gaining support and involvement of workforce, Reducing risk instances, Accident reduction objective.

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